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A. Suneetha ¹, B. Syama Sundar ²

Affiliations
1 Department of Pharmaceutical Analysis, Hindu College of Pharmacy, Amaravathi Road, Guntur (A.P), IN
2 Department of Pharmacy, Acharya Nagarjuna University, Nagarjuna Nagar, Guntur (A.P), IN

Abstract

A simple, sensitive, precise, accurate and economical spectrophotometric method of analysis for escitalopram oxalate both as a bulk drug and in tablet dosage forms was developed and validated. The method employed methanol as solvent and the drug shows maximum absorbance at 239 nm with molar absorptivity of 0.1742×10⁵ L/mol.cm. The linear regression analysis data for the calibration plot showed good linear relationship with r² = 0.9999 in the concentration range of 5-25 μg/ml. Results of analysis were validated statistically and by recovery studies.

Keywords

Escitalopram Oxalate, U.V Spectrophotometry, Tablets.

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A. Suneetha ¹, B. Syama Sundar ²

Affiliations
1 Department of Pharmaceutical Analysis, Hindu College of Pharmacy, Amaravathi Road, Guntur-522002, IN
2 Department of Chemistry/Pharmacy, Acharya Nagarjuna University, Nagarjuna Nagar, Guntur-522510, IN

Abstract

A new simple, sensitive, precise, accurate and economical UV spectrophotometric method of analysis for almotriptan malate both as a bulk drug and in tablet formulations was developed and validated. The method employed methanol as solvent and the drug shows maximum absorbance at 227 nm with molar absorptivity of 0.8532×10⁵ L/mol.cm. The linear regression analysis data for the calibration plot showed good linear relationship with r²=0.9999 in the concentration range of 1-5 μg/ml. Results of analysis were validated statistically and by recovery studies.

Keywords

Almotriptan Malate, U.V Spectrophotometry, Tablets.

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